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Case Reports
. 2018 Nov 19:26:45-49.
doi: 10.1016/j.rmcr.2018.11.011. eCollection 2019.

Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report

Masatoshi Yamazoe  1 , Hiromi Tomioka  1 , Takahiro Kamada  2 , Masahiro Kaneko  1 , Eiji Katsuyama  3
Affiliations
Case Reports

Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report

Masatoshi Yamazoe et al. Respir Med Case Rep. .

Abstract

The co-presence of malignant pleural mesothelioma (MPM) and lung cancer is rare. We report a 70-year-old male with exposure to asbestos. Chest computed tomography revealed a right mediastinal mass combined with an enlarged ipsilateral lymph node and left pleural effusion. Transbronchial lung biopsy revealed lung adenocarcinoma. Thoracoscopic examination revealed multiple left pleural nodules, leading to the diagnosis of MPM. Despite aggressive anticancer drug therapy, he expired due to disease progression 2.5 years after diagnosis. Autopsy confirmed an epithelioid MPM in the left pleura. MPM comorbidity in patients diagnosed with lung cancer should be considered, especially in those exposed to asbestos.

Keywords: Autopsy; Lung cancer; Malignant pleural mesothelioma; Multiple primary cancer; Simultaneous.

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Figures

Fig. 1
Fig. 1
Chest CT revealed the presence of a right mediastinal mass combined with an enlarged right lymph node and left pleural effusion CT: computed tomography.
Fig. 2
Fig. 2
Thoracoscopic examination revealed the presence of multiple white small nodules on the left precordial parietal pleura (a) and a coral-shaped nodule on the diaphragm (b).
Fig. 3
Fig. 3
Chest CT showed right bronchial obstruction due to the enlarged right mediastinal lymph node and bronchial tumor. However, it did not show thickening of the left pleura. CT: computed tomography.
Fig. 4
Fig. 4
Epithelioid malignant mesothelioma in the left parietal pleura detected at autopsy. (×10) (a) HE, hematoxylin and eosin; (b) Calretinin (c) TTF-1, thyroid transcription factor-1.
Fig. 5
Fig. 5
Epithelioid malignant mesothelioma in the left diaphragm detected at autopsy. (×10) (a) Calretinin (b) TTF-1, thyroid transcription factor-1.
Fig. 6
Fig. 6
Lung adenocarcinoma forming a right mediastinal mass detected at autopsy. (×10) (a) Calretinin (b) TTF-1, thyroid transcription factor-1.
See this image and copyright information in PMC

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