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. 2018 Nov 23;4(1):17-21.
doi: 10.1016/j.bioactmat.2018.11.002. eCollection 2019 Mar.

A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light

Bo Huang  1 , Lei Tan  1 , Xiangmei Liu  1 , Jun Li  2 , Shuilin Wu  1   2
Affiliations

A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light

Bo Huang et al. Bioact Mater. .

Erratum in

Abstract

Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment in vivo. Thus, the development of novel implant materials is quite urgent. Red phosphorus has great biocompatibility and exhibits efficient photothermal ability. Herein, a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine (RGDC) coating on titanium bone-implant was prepared. The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of ROS produced by IR780 with 808 nm light irradiation. With keeping the cells and tissues normal, a high antibacterial performance can be realized by near-infrared (808 nm) irradiated within 10 min at 50 °C. Besides the high effective antibacterial efficacy provided by photothermal therapy (PTT) and photodynamic therapy (PDT), the RGDC decorated surface can also possess an excellent performance in osteogenesis in vivo.

Keywords: Antibacterial; Biofilm; Implants; Near-infrared; Osteogenesis; Red phosphorus.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
The chemical formula of (a) IR780, and (b) RGDC, (c) SEM images of Ti-RP. (d) TEM image of RP separated from Ti-RP, the scale bar fixed with 200 nm and 5 nm, respectively.
Fig. 2
Fig. 2
(a) ROS detection of Ti, Ti-RP(50 °C), Ti-RP-IR780-RGDC(25 °C), Ti-RP-IR780-RGDC(50 °C). (b) Cycle heating curve of Ti-RP-IR780-RGDC.
Fig. 3
Fig. 3
(a) Photograph of bacteria colonies and culture mediums of Ti+Light and Ti-RP-IR780-RGDC+Light rods taken from rats. (b,c) H&E staining images show tissue infection degree of rats treated by samples.
Fig. 4
Fig. 4
(a) Histological characteristics at the Bone-implant interfaces stained with Van Gieson's picro fuchsin (scale bars = 500 μm); (b) Percentage of new bone area (**P < 0.01); (c) Micro-CT images of the coronal sections.
See this image and copyright information in PMC

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