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Review
. 2018 Nov-Dec;23(6):495-502.
doi: 10.1016/j.rpor.2018.04.004. Epub 2018 May 9.

Present status of sentinel lymph node biopsy in cervical cancer

Ariel Gustavo Glickman  1 , Sergio Valdes  1 , Blanca Gil-Ibañez  1 , Pilar Paredes  2 , Karen Sttephannía Cortés  3 , Aureli Angel Torné Blade  1
Affiliations
Review

Present status of sentinel lymph node biopsy in cervical cancer

Ariel Gustavo Glickman et al. Rep Pract Oncol Radiother. 2018 Nov-Dec.

Abstract

Cervical cancer is the fourth most common cancer in women, and seventh overall. This disease represents a medical, economic and social burden. In early FIGO stage patients (IA, IB1 and IIA1), nodal involvement is the most important prognostic factor. Imaging evaluation of nodal metastasis is of limited value. In order to determine lymph node involvement, allow loco-regional control of the disease, define the need for adjuvant radiotherapy and improve survival, standard surgery for early disease is radical hysterectomy with systematic pelvic lymphadenectomy. However, this surgical treatment has risks and complications: longer operative time, larger blood loss, neurovascular or ureteral injury, lower-limb lymphedema, symptomatic lymphocysts, hydronephrosis. A method that allows to define the presence of regional metastasis with less morbidity and equal or greater precision is particularly relevant. The use of the sentinel lymph node biopsy is intended to reach that purpose. The present study reviews recent literature on the role of sentinel lymph node biopsy in cervical cancer, analyzing its indications and contraindications, injection and detection techniques, tracers used, surgical and pathological approaches and its applicability in up-to-date clinical practice.

Keywords: Cervical cancer; Clinical relevance; Detection rate; Injection techniques and tracers; Sensitivity; Sentinel lymph node biopsy.

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Figures

Fig. 1
Fig. 1
Cartographed localization of SLN by Marnitz et al.
Fig. 2
Fig. 2
Surgical algorithm for SLN biopsy by Cormier et al. (a) Intracervical injection; (b) including interiliac/subaortic nodes; (c) exceptions made for select cases.
See this image and copyright information in PMC

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