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. 1988 Dec;56(12):3313-5.
doi: 10.1128/iai.56.12.3313-3315.1988.

Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens

S E Valone  1 , E A Rich, R S Wallis, J J Ellner
Affiliations

Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens

S E Valone et al. Infect Immun. 1988 Dec.

Abstract

Four mycobacterial preparations directly stimulated human blood monocytes and alveolar macrophages to produce tumor necrosis factor (TNF). Monoclonal antibody against TNF blocked (99%) TNF activity. Lipopolysaccharide was not responsible for the TNF activity generated; activity was unaffected in the presence of polymyxin B.

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