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. 2018 Oct 25;4(11):e404.
doi: 10.1097/TXD.0000000000000844. eCollection 2018 Nov.

Retransplantation Outcomes at a Large Lung Transplantation Program

Dewei Ren  1 , Thomas S Kaleekal  2 , Edward A Graviss  3 , Duc T Nguyen  3 , Neeraj Sinha  4 , Amad Goodarzi  2 , Isioma Agboli  5 , Erik E Suarez  1 , Matthias Loebe  4 , Scott A Scheinin  6 , Brian A Bruckner  1
Affiliations

Retransplantation Outcomes at a Large Lung Transplantation Program

Dewei Ren et al. Transplant Direct. .

Abstract

Background: With the increase of primary lung transplantation across major centers worldwide, over the last several years the need of lung retransplant (ReTX) is likely to increase. Therefore, characterization of ReTX patients is prudent and necessary. Our study aimed to investigate and characterize the covariates and outcomes associated with lung ReTX survival in a single large U.S. transplant center.

Methods: Demographic, clinical diagnoses, and comorbidities were analyzed. Kaplan-Meier statistics were used to calculate and predict survival for 30 days and up to 3 years. Cox proportional modeling was used to determine the variables associated with mortality.

Results: Of included 684 lung transplants performed at the Houston Methodist Hospital between January 2009 and December 2015, 49 were lung ReTX. Median age of primary lung transplant (non-ReTX) and ReTx recipients was 62 and 49 years, respectively. Chronic graft rejection in the form of restrictive chronic lung allograft dysfunction and bronchiolitis obliterans syndrome was the main indications for ReTX. Compared with non-ReTX patients, ReTX patients had higher median lung allocation score (46.2 vs 37.0, respectively) and higher mortality after 6 months posttransplant. ReTX, older age, female sex, hospitalization 15 days or longer, estimated glomerular filtration rate less than 60, 6-minute walk distance less than 400 ft, and donor/recipient height ratio less than 1 were significantly associated with decreased 1-year patient and graft survival. Chronic graft rejection was still the major cause of death in the long-term follow-up recipients.

Conclusions: Our findings suggested that lung ReTX recipients have poor long-term survival outcomes. Lung ReTX should only be offered to carefully selected patients.

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Conflict of interest statement

The authors declare no funding or conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the study population.
FIGURE 2
FIGURE 2
Kaplan-Meier 3-year survival curves in lung transplant recipients at Houston Methodist Hospital, 2009-2015.
See this image and copyright information in PMC

References

    1. Yusen RD, Edwards LB, Kucheryavaya AY, et al. The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report—2014; focus theme: retransplatation. J Heart Lung Transplant. 2014;33:1009–1024. - PubMed
    1. Organ Procurement and Transplantation Network. Lung Kaplan-Meier patient survival rates for transplants performed: 2008-2015. Available at https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/#. Accessed on December 19, 2017.
    1. Organ Procurement and Transplantation Network - OPTN. Policy 10.1.F.i lung disease diagnosis groups. Available at https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf. Accessed on March 8, 2018.
    1. Sommer W, Ius F, Kühn C, et al. Technique and outcomes of less invasive lung retransplantation. Transplantation. 2018;102:530–537. - PubMed
    1. Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest. 2017;152:627–638. - PubMed