Detection of Cryptococcus DNA by Metagenomic Next-generation Sequencing in Symptomatic Cryptococcal Antigenemia

Prashanth S Ramachandran¹, Fiona V Cresswell^{2

3}, David B Meya^{2

4}, Charles Langelier^{5

6}, Emily D Crawford^{6

7}, Joseph L DeRisi^{6

7}, David R Boulware⁴, Michael R Wilson¹

Affiliations

¹ Department of Neurology, University of California at San Francisco.
² Infectious Diseases Institute, Makerere University, Kampala, Uganda.
³ Clinical Research Department, London School of Hygiene and Tropical Medicine, United Kingdom.
⁴ Department of Medicine, University of Minnesota, Minneapolis.
⁵ Division of Infectious Diseases, Department of Medicine, University of California, San Francisco.
⁶ Chan Zuckerberg Biohub, University of California at San Francisco.
⁷ Department of Biochemistry and Biophysics, University of California at San Francisco.

Comment

Prashanth S Ramachandran et al. Clin Infect Dis. 2019.

. 2019 May 17;68(11):1978-1979.

doi: 10.1093/cid/ciy1024.

Prashanth S Ramachandran¹, Fiona V Cresswell^{2

3}, David B Meya^{2

4}, Charles Langelier^{5

6}, Emily D Crawford^{6

7}, Joseph L DeRisi^{6

7}, David R Boulware⁴, Michael R Wilson¹

¹ Department of Neurology, University of California at San Francisco.
² Infectious Diseases Institute, Makerere University, Kampala, Uganda.
³ Clinical Research Department, London School of Hygiene and Tropical Medicine, United Kingdom.
⁴ Department of Medicine, University of Minnesota, Minneapolis.
⁵ Division of Infectious Diseases, Department of Medicine, University of California, San Francisco.
⁶ Chan Zuckerberg Biohub, University of California at San Francisco.
⁷ Department of Biochemistry and Biophysics, University of California at San Francisco.

No abstract available

Keywords: HIV; cryptococcal antigenemia; meningitis; metagenomic next-generation sequencing.

Comment on

Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis With Negative Cerebral Spinal Fluid Analysis.
Ssebambulidde K, Bangdiwala AS, Kwizera R, Kandole TK, Tugume L, Kiggundu R, Mpoza E, Nuwagira E, Williams DA, Lofgren SM, Abassi M, Musubire AK, Cresswell FV, Rhein J, Muzoora C, Hullsiek KH, Boulware DR, Meya DB; Adjunctive Sertraline for Treatment of HIV-associated Cryptococcal Meningitis Team. Ssebambulidde K, et al. Clin Infect Dis. 2019 May 30;68(12):2094-2098. doi: 10.1093/cid/ciy817. Clin Infect Dis. 2019. PMID: 30256903 Free PMC article.

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