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. 2018 Dec 15;34(24):4310-4312.
doi: 10.1093/bioinformatics/bty539.

pyseer: a comprehensive tool for microbial pangenome-wide association studies

Affiliations

pyseer: a comprehensive tool for microbial pangenome-wide association studies

John A Lees et al. Bioinformatics. .

Abstract

Summary: Genome-wide association studies (GWAS) in microbes have different challenges to GWAS in eukaryotes. These have been addressed by a number of different methods. pyseer brings these techniques together in one package tailored to microbial GWAS, allows greater flexibility of the input data used, and adds new methods to interpret the association results.

Availability and implementation: pyseer is written in python and is freely available at https://github.com/mgalardini/pyseer, or can be installed through pip. Documentation and a tutorial are available at http://pyseer.readthedocs.io.

Supplementary information: Supplementary data are available at Bioinformatics online.

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References

    1. Brynildsrud O. et al. (2016) Rapid scoring of genes in microbial pan-genome-wide association studies with scoary. Genome Biol., 17, 238.. - PMC - PubMed
    1. Earle S.G. et al. (2016) Identifying lineage effects when controlling for population structure improves power in bacterial association studies. Nat. Microbiol., 1, 16041.. - PMC - PubMed
    1. Garland T., Ives A.R. (2000) Using the past to predict the present: confidence intervals for regression equations in phylogenetic comparative methods. Am. Nat., 155, 346–364. - PubMed
    1. Hadfield J. et al. (2018) Phandango: an interactive viewer for bacterial population genomics. Bioinformatics, 34, 292–293. - PMC - PubMed
    1. Heinze G., Schemper M. (2002) A solution to the problem of separation in logistic regression. Stat. Med., 21, 2409–2419. - PubMed

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