Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019:1916:195-201.
doi: 10.1007/978-1-4939-8994-2_18.

Characterization of the db/db Mouse Model of Type 2 Diabetes

Paul C Guest  1 , Hassan Rahmoune  2
Affiliations

Characterization of the db/db Mouse Model of Type 2 Diabetes

Paul C Guest et al. Methods Mol Biol. 2019.

Abstract

This chapter presents characterization of the db/db mouse model of type 2 diabetes. The protocol describes generation of the mice along with measurements of physical characteristics such as body weight and body composition, and behaviours including food and water consumption. Such a procedure can also be used for omics-based analyses of brain tissues to investigate the potential use of db/db mouse model in neuropsychiatric research. In addition, we present measurement of blood glucose and plasma insulin levels which tend to be elevated in this model and can modulated post treatment with anti-diabetic agents. All of these characteristics can be used for studying the pathophysiology and for monitoring response to potential therapeutics.

Keywords: Biomarkers; Diabetes; Immunoassay; Metabolic; Mouse model.

PubMed Disclaimer

LinkOut - more resources