Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure

Abstract

Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR) estimates are included in the meta-analysis. Weighted median OR was calculated for five radon intervals. The following parameters were used for the weighting: standard error of OR, duration of radon concentration measurement, and relative number of controls in reference intervals. The dependence of the weighted median OR on the radon concentration was estimated applying linear non-threshold and threshold models. The results obtained suggest a significant linear no-threshold exposure-effect relationship for radon concentrations above 100 Bq/m³, with a slope of 0.14 (95% confidence interval 0.08-0.21) per 100 Bq/m³.

Keywords: Lung cancer; Meta-analysis; Non-threshold relationship; Radon; Risk.