Psychiatric comorbidy in Ullrich-Turner syndrome

Abstract

Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.

Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature.

Conclusion: Several current reports about the frequent occurrence of psychotic symptoms in TS suggest a relationship between X-chromosomal aberration and schizophrenic disorders. Regarding to comorbidity, however, a universally valid nosological categorization is required, which would also facilitate further necessary research activity.