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. 2018 Nov 13:2018:8250589.
doi: 10.1155/2018/8250589. eCollection 2018.

Encapsulating Peritoneal Sclerosis in Long-Termed Peritoneal Dialysis Patients

Heng-Jung Hsu  1   2   3   4 , Shih-Ying Yang  1   2 , I-Wen Wu  1   2   4 , Kuang-Hung Hsu  5   6   7   8 , Chiao-Yin Sun  1   2   4 , Chun-Yu Chen  1   2 , Chin-Chan Lee  1   2   4
Affiliations

Encapsulating Peritoneal Sclerosis in Long-Termed Peritoneal Dialysis Patients

Heng-Jung Hsu et al. Biomed Res Int. .

Abstract

Background: Encapsulating peritoneal sclerosis (EPS) is a rare but serious clinical complication of long-term peritoneal dialysis (PD) patients with high mortality. The purpose of this study was to assess the clinical characteristics of patients with EPS and to search for possible factors useful for EPS prevention and early diagnosis.

Method: This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Overall, a total of 565 patients were included and the medical records of those patients who had developed EPS (EPS group) and those who had not developed EPS (control group) were collected. We compared several factors between these two groups.

Result: In the univariate analysis, EPS was significantly associated with a change of transport state (Delta 2) (p = 0.007), duration of PD (p < 0.001), duration of peritonitis treatment (p = 0.001), number of peritonitis episodes (p = 0.002), and fungus related peritonitis (p = 0.031). After multivariate logistic model analysis, we found that only the duration of PD was independently significantly associated with EPS (p = 0.034). In addition, we used the ROC curve and found that a duration of peritoneal dialysis of about 8.4 years is the best cut-off point to predict EPS occurrence.

Conclusion: In this study, long-termed PD duration is the only strong independent risk factor for EPS development. Total peritonitis times, total peritonitis treatment duration, and marked increased peritoneal D/Pcr ratio were also significantly associated with the duration of PD.

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Figures

Figure 1
Figure 1
The receiver operating characteristic (ROC) curves for total peritonitis times, total peritonitis duration, and the duration of PD in predicting occurrence of encapsulating peritonitis sclerosis on CKD patients on peritoneal dialysis.
See this image and copyright information in PMC

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