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Review
. 2018 Dec;29(4):419-433.
doi: 10.1007/s13337-018-0492-y. Epub 2018 Sep 29.

Role of viruses, prions and miRNA in neurodegenerative disorders and dementia

Sayed Sartaj Sohrab  1 , Mohd Suhail  2 , Ashraf Ali  2 , Mohammad Amjad Kamal  2   3   4 , Azamal Husen  5 , Fahim Ahmad  6 , Esam Ibraheem Azhar  1   7 , Nigel H Greig  8
Affiliations
Review

Role of viruses, prions and miRNA in neurodegenerative disorders and dementia

Sayed Sartaj Sohrab et al. Virusdisease. 2018 Dec.

Abstract

Dementia is known as loss of cellular communications in the brain at a region caused by multi-factorial diseases and pathogenic infections. Approximately eighty percent reported cases of Alzheimer's disease are followed by vascular dementia. The common symptoms of dementia include memory loss, concentration problems, thinking, and language solving situations. Dementia is a multifactorial disease but based on latest research; various reports have been published describing the linkage and role of viruses, prions and miRNAs in neurodegeneration and neurodegenerative disorders resulting into dementia and due to this we selected to review and provide latest information related to dementia. MiRNAs are small non-coding RNAs carrying genetic regulatory information contributing to neurological disorders among human and animals. A prion is an infectious agent made of protein material. Recently, it has been reported that prions play a significant role in signaling processes, resulting in amyloidogenesis and neurological disorders. Viruses attack human immune system and central nervous system and affect classical pathways of neurodegenerative diseases. Comprehensive understandings of the expression profiles and activities of these miRNAs, Prions, Viruses will illuminate their roles as potential therapeutic targets in neurodegeneration and may lead to the discovery of breakthrough treatment strategies for neurodegenerative disorders and dementia. The provided information will further be significant not only in neuro-scientific research, but also in designing and development of management strategies for dementia.

Keywords: Dementia; Neurodegeneration; Prions; Viruses; miRNAs.

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Figures

Fig. 1
Fig. 1
Virus infection leads to development of neurodegeneration and dementia
See this image and copyright information in PMC

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