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Review
. 2019:1897:107-114.
doi: 10.1007/978-1-4939-8935-5_11.

Biobanking of Cerebrospinal Fluid

Randy S Tashjian  1 , Harry V Vinters  1 , William H Yong  2   3   4
Affiliations
Review

Biobanking of Cerebrospinal Fluid

Randy S Tashjian et al. Methods Mol Biol. 2019.

Abstract

Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. This chapter outlines the procedures necessary to collect, process, store, and utilize CSF obtained for the purposes of biobanking from both living and deceased patients.

Keywords: Aliquoting; Biobanking; Centrifugation; Cerebrospinal fluid (CSF); Collection; Storage; Transport.

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References

    1. Ma MJ, Perry A, Brat DJ (2010) Biopsy pathology of neurodegenerative disorders in adults In: Practical Surgical Neuropathology: A Diagnostic Approach. Churchill Livingstone/Elsevier, Philadelphia, p. 566–570.
    1. Ellison D, Love S, Chimelli L, et al. (2013) Prion diseases In: Neuropathology: A Reference Text of CNS Pathology (Third Edition). Mosby/Elsevier, p. 676.
    1. Willemse EA and Teunissen CE (2015) Biobanking of cerebrospinal fluid for biomarker analysis in neurological diseases In: Karimi-Busheri F. Ed. Biobanking in the 21st Century. Springer International Publishing, Switzerland, pp. 79–93. - PubMed
    1. Brat DJ (2010) Normal brain histopathology In: Perry A and Brat DJ Ed. Practical Surgical Neuropathology: A Diagnostic Approach. Churchill Livingstone/Elsevier, Philadelphia, p. 20.
    1. Martino G, Grimaldi LM, Moiola L, et al. (1990) Discontinuous distribution of IgG oligoclonal bands in cerebrospinal fluid from multiple sclerosis patients. J Neuroimmunol 30 (2–3), 129–134. - PubMed

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