Identifying New Epigenetic Drivers of Liver Fibrosis

Affiliations

¹ Center for Liver Diseases, Pittsburgh Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
² Center for Liver Diseases, Pittsburgh Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: bataller@pitt.edu.

Editorial

Josepmaria Argemi et al. Cell Mol Gastroenterol Hepatol. 2019.

. 2019;7(1):237-238.

doi: 10.1016/j.jcmgh.2018.09.015. Epub 2018 Oct 19.

¹ Center for Liver Diseases, Pittsburgh Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
² Center for Liver Diseases, Pittsburgh Research Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: bataller@pitt.edu.

No abstract available

Comment on

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.
Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH. Martin-Mateos R, et al. Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. doi: 10.1016/j.jcmgh.2018.09.005. Epub 2018 Sep 15. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30539787 Free PMC article.

1. Vilar-Gomez E., Calzadilla-Bertot L., Wai-Sun Wong V., Castellanos M., Aller-de la Fuente R., Metwally M., Eslam M., Gonzalez-Fabian L., Alvarez-Quiñones Sanz M., Conde-Martin A.F., De Boer B., McLeod D., Hung Chan A.W., Chalasani N., George J., Adams L.A., Romero-Gomez M. Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology. 2018;155:443–457.e17. - PubMed
1. Tsuchida T., Friedman S.L. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14:397–411. - PubMed
1. Massey V., Cabezas J., Bataller R. Epigenetics in liver fibrosis. Semin Liver Dis. 2017;37:219–230. - PubMed
1. Mann J., Chu D.C., Maxwell A., Oakley F., Zhu N.L., Tsukamoto H. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010;138:705–714. 714 e1–4. - PMC - PubMed
1. Martin-Mateos R., De Assuncao T.M., Arab J.P., Jalan-Sakrikar N., Yaqoob U., Greuter T., Verma V.K., Mathison A.J., Cao S., Lomberk G., Mathurin P., Urrutia R., Huebert R.C., Shah V.H. Enhancer of zeste homologue 2 inhibition attenuates TGF-β dependent hepatic stellate cell activation and liver fibrosis. Cell Mol Gastroenterol Hepatol. 2019;7:197–209. - PMC - PubMed