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Multicenter Study
. 2018 Dec 12;18(1):189.
doi: 10.1186/s12871-018-0651-0.

Cell salvage using the continuous autotransfusion device CATSmart - an observational bicenter technical evaluation

Simone Lindau  1 , Madeline Kohlhaas  1 , Michael Nosch  2 , Suma Choorapoikayil  1 , Kai Zacharowski  1 , Patrick Meybohm  3
Affiliations
Multicenter Study

Cell salvage using the continuous autotransfusion device CATSmart - an observational bicenter technical evaluation

Simone Lindau et al. BMC Anesthesiol. .

Abstract

Background: The use of cell salvage and autologous blood transfusion has become an important method of blood conservation. So far, there are no clinical data about the performance of the continuous autotransfusion device CATSmart.

Methods: In total, 74 patients undergoing either cardiac or orthopedic surgery were included in this prospective, bicenter and observational technical evaluation to validate red cell separation process and washout quality of CATSmart. The target of red cell separation process was defined as a hematocrit value in the packed red cell unit of 55-75% and of washout quality of 80-100% removal ratio.

Results: Hematocrit values measured by CATSmart and laboratory analysis were 78.5% [71.3%; 84.0%] and 73.7% [67.5%; 75.5%], respectively. Removal ratios for platelets 94.7% [88.2%; 96.7%], free hemoglobin 89.3% [85.2%; 94.9%], albumin 97.9% [96.6%; 98.5%], heparin 99.9% [99.9%; 100.0%], and potassium 92.5% [90.8%; 95.0%] were within the target range while removal of white blood cells was slightly worse 72.4% [57.9%; 87.3%].

Conclusion: The new autotransfusion device enables sufficient red cell separation and washout quality.

Keywords: Auto transfusion; Cell salvage; Hematocrit value.

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Conflict of interest statement

Ethics approval and consent to participate

The ethics committee of the University Hospital Frankfurt approved the protocol addressing patients undergoing cardiac surgery (approval ref. 80/15). A written consent of the participations was not required according to national regulations (German Constitution Art. 72, Berufsordnung für Ärzte §15, HeilBerG Nordrhein-Westfalen §7). This technical evaluation was not required and thus not submitted to IRB of the Marienhospital Bottrop (Ärztekammer Westfalen Lippe) according to regional and national regulations (German Constitution Art. 72, Berufsordnung für Ärzte §15, HeilBerG Nordrhein-Westfalen §7).

Consent for publication

Not applicable.

Competing interests

PM and KZ received grants from B. Braun Melsungen, CSL Behring, Fresenius Kabi, and Vifor Pharma for the implementation of Frankfurt‘s Patient Blood Management program and honoraria for scientific lectures from B. Braun Melsungen, Vifor Pharma, Fearing, CSL Behring, and Pharmacosmos.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flowchart of participants
Fig. 2
Fig. 2
Red cell separation performance defined by hematocrit values. Data are presented as median [25%;75%]. Hematocrit (Hct) values are shown before (IN, shed blood) and after blood processing (OUT, packed red cells) by central laboratory (LAB) and CATSmart.
Fig. 3
Fig. 3
Hematocrit values in RBC concentrates. Hct values of the packed red cell concentrate measured by CATSmart and the laboratory (LAB) significantly correlated (r = 0.51; p ≤ 0.05).
Fig. 4
Fig. 4
Washout quality defined by removal ratio (%) of multiple blood parameters for each of the 50 analyzed patients. WBC = white blood cells; Plt = platelets; Alb = albumin; fHb = free hemoglobin; aXa = heparin; K+ = potassium.
See this image and copyright information in PMC

References

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