Response to comment on "ALK is a therapeutic target for lethal sepsis"

Daolin Tang^{1

2

3}, Rui Kang^{2

3}

Affiliations

¹ The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510510, China. daolin.tang@utsouthwestern.edu.
² Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
³ Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Comment

Daolin Tang et al. Sci Transl Med. 2018.

. 2018 Dec 12;10(471):eaas9817.

doi: 10.1126/scitranslmed.aas9817.

Daolin Tang^{1

2

3}, Rui Kang^{2

3}

¹ The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510510, China. daolin.tang@utsouthwestern.edu.
² Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
³ Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

ALK inhibitors may exhibit STING-independent anti-inflammatory activity in macrophages and monocytes.

ALK is a therapeutic target for lethal sepsis.
Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, Billiar TR, Jiang J, Tang D. Zeng L, et al. Sci Transl Med. 2017 Oct 18;9(412):eaan5689. doi: 10.1126/scitranslmed.aan5689. Sci Transl Med. 2017. PMID: 29046432 Free PMC article.
Comment on "ALK is a therapeutic target for lethal sepsis".
Blasco RB, Patrucco E, Mota I, Tai WT, Chiarle R. Blasco RB, et al. Sci Transl Med. 2018 Dec 12;10(471):eaar4321. doi: 10.1126/scitranslmed.aar4321. Sci Transl Med. 2018. PMID: 30541790 Free PMC article.