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Review
. 2018 Nov 22:7:F1000 Faculty Rev-1835.
doi: 10.12688/f1000research.16509.1. eCollection 2018.

Ovarian ageing and the impact on female fertility

Beverley Vollenhoven  1   2   3 , Sarah Hunt  1   2   3
Affiliations
Review

Ovarian ageing and the impact on female fertility

Beverley Vollenhoven et al. F1000Res. .

Abstract

Female fertility decreases with increasing age, a reflection of declining oocyte quantity and quality. The menopausal transition occurs when the oocyte quantity falls below a threshold level. The pattern of follicular depletion as well as the factors, timing and mechanisms surrounding both declining oocyte number and oocyte quality remain incompletely understood. Further studies are needed to examine the factors involved and develop predictive models and biomarkers to assist in the management of age-related subfertility. This review summarises the current knowledge addressing the ageing ovary and its impact on fertility.

Keywords: Age; assisted reproductive technologies; fertility; oocyte.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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    2. F1000 Recommendation