Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 May 15;199(10):1178-1181.
doi: 10.1164/rccm.201811-2163ED.

Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-associated Pneumonia

Samir Gautam  1 , Lokesh Sharma  1 , Charles S Dela Cruz  1
Affiliations
Comment

Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-associated Pneumonia

Samir Gautam et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Pneumonic immune responses. Under healthy conditions (left panel), low levels of commensal bacteria and resting, noninflammatory macrophages predominate. The mechanically ventilated lung (top right panel) has numerous immune stimuli, for example, relating to volutrauma-induced tissue damage and systemic inflammation. These factors lead to endothelial activation and immune infiltrate, but not overt pneumonia. During ventilator-associated pneumonia (depicted in the bottom right panel), pathogenic bacteria further activate macrophages and induce both damage and stimulation of epithelial cells. Together, these drive a robust pyogenic inflammatory response, which may be detected by either one of the diagnostic methods described here.
See this image and copyright information in PMC

Comment on

  • Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.
    Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N, McQuattie-Pimentel AC, Chen CI, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Aillon RP, Watanabe S, Williams KJN, Lu Z, Paonessa J, Hountras P, Breganio M, Borkowski N, Donnelly HK, Allen JP, Amaral LA, Bharat A, Misharin AV, Bagheri N, Hauser AR, Budinger GRS, Wunderink RG. Walter JM, et al. Am J Respir Crit Care Med. 2019 May 15;199(10):1225-1237. doi: 10.1164/rccm.201804-0650OC. Am J Respir Crit Care Med. 2019. PMID: 30398927 Free PMC article.

References

    1. O’Neill J. Tackling drug-resistant infections globally: final report and recommendations. The review on antimicrobial resistance; 2016 [accessed 2018 Apr 16]. Available from: https://amr-review.org/sites/default/files/160518_Final%20paper_with%20c....
    1. Gautam S, Sharma L, Dela Cruz CS. Personalizing the management of pneumonia. Clin Chest Med. 2018;39:871–900. - PubMed
    1. Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, Dunn JR, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372:825–834. - PMC - PubMed
    1. Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernández-Delgado E, Herrera-Melero I, et al. De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med. 2014;40:32–40. - PubMed
    1. Schuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, et al. Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis. Lancet Infect Dis. 2018;18:95–107. - PubMed