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Meta-Analysis
. 2018 Dec;97(49):e13528.
doi: 10.1097/MD.0000000000013528.

Association between Helicobacter pylori infection and Sjögren syndrome: A meta-analysis

Qianqian Chen  1   2 , Xiaoying Zhou  1   3 , Wenfeng Tan  1   2 , Miaojia Zhang  1   2
Affiliations
Meta-Analysis

Association between Helicobacter pylori infection and Sjögren syndrome: A meta-analysis

Qianqian Chen et al. Medicine (Baltimore). 2018 Dec.

Abstract

Background: Helicobacter pylori has been proved as a risk factor of many diseases. There are some researches trying to find connection between H. pylori and Sjögren syndrome (SS). However, the conclusions of these studies are controversial. We conducted this meta-analysis to evaluate the association between H. pylori and SS.

Methods: We searched PubMed and Embase databases for researches which include the data of H. pylori infection rate in SS and control groups. A fixed-effects model was used to analyze the risk odds ratio (OR) with 95% confidence intervals (CIs) according to the heterogeneity across the selected studies.

Results: Nine studies with 1958 participants including 619 patients with SS met the inclusion criteria. The total infection rate of H. pylori was 53.83% (1054/1958). We found that the patients with SS had a significantly higher H. pylori infection rate than control groups (OR = 1.19, 95% CI: 1.01-1.41, P = .033). Subgroup analysis demonstrated a significantly higher H. pylori infection rate in patients with primary SS than controls (OR = 1.24, 95% CI: 1.03-1.50, P = .026).

Conclusion: This meta-analysis is the 1st meta-analysis about the association between H. pylori and SS. The pooled data suggested a significantly higher H. pylori infection rate in patients with SS. More prospective or multicenter retrospective researches could be conducted in the future.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Forest plot about association between Helicobacter pylori infection and Sjögren syndrome.
Figure 2
Figure 2
Meta-analysis of primary Sjögren syndrome groups of the selected studies.
Figure 3
Figure 3
Meta-analysis of secondary Sjögren syndrome groups of the selected studies.
Figure 4
Figure 4
subgroup analysis according to the different detection ways of Helicobacter pylori infection.
Figure 5
Figure 5
Funnel plot of publication bias.
Figure 6
Figure 6
Publication bias with Egger test.
Figure 7
Figure 7
Publication bias with Begg test.
See this image and copyright information in PMC

References

    1. Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori Infection. Helicobacter 2014;19:1–5. - PubMed
    1. Kuipers EJ, Uyterlinde AM, Pena AS, et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet (London, England) 1995;345:1525–8. - PubMed
    1. Raderer M, Kiesewetter B, Ferreri AJ. Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). CA Cancer J Clin 2016;66:153–71. - PubMed
    1. Chey WD, Leontiadis GI, Howden CW, et al. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol 2017;112:212–39. - PubMed
    1. Jackson S, Beck PL, Pineo GF, et al. Helicobacter pylori eradication: novel therapy for immune thrombocytopenic purpura? A review of the literature. Am J Hematol 2005;78:142–50. - PubMed

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