Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Dec 12;10(12):1963.
doi: 10.3390/nu10121963.

Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Minkyeong Kim  1 , Kyong Park  2
Affiliations
Meta-Analysis

Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Minkyeong Kim et al. Nutrients. .

Abstract

Dietary fat intake is associated with the risk of colorectal cancer (CRC); however, the results of epidemiological studies on this are controversial. Therefore, this study aimed to summarize the available scientific evidence regarding the association between dietary fat and the risk of CRC. We conducted a systematic search of PubMed, Web of Science, and the Cochrane library for articles related to dietary fat and the risk of CRC. The summary relative risks with 95% confidence intervals (CI) were calculated via a random effect model. Begg's test was used to detect publication bias. A total of 18 articles were identified. The pooled relative risk with 95% CI for the risk of CRC were 1.00 (95% CI: 0.90⁻1.12), 0.97 (95% CI: 0.86⁻1.10), 1.08 (95% CI: 0.92⁻1.26), and 0.99 (95% CI: 0.93⁻1.04) for total fat, saturated fatty acid, monounsaturated fatty acid, and polyunsaturated fatty acid, respectively. No significant associations were found in subgroup analyses. Begg's test for all exposures revealed no publication bias (total fat, p = 0.3; saturated fatty acid, p = 0.1; monounsaturated fatty acid, p = 0.08; polyunsaturated fatty acid, p = 0.2). The studies included in this review and meta-analysis revealed that dietary fats and fatty acids had no effects on the risk of CRC.

Keywords: colorectal neoplasms; dietary fats; fatty acids; meta-analysis; systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram for study selection.
Figure 2
Figure 2
Forest plot of pooled estimates of the association between dietary fat and fatty acid intake and risk of colorectal cancer. (a) Total fat intake and risk of colorectal cancer; (b) saturated fat or fatty acid and colorectal cancer; (c) monounsaturated fat or fatty acid and colorectal cancer; and (d) polyunsaturated fat or fatty acid and colorectal cancer. CI, confidence interval; n-3, omega-3 fatty acids; n-6, omega-6 fatty acids.
Figure 2
Figure 2
Forest plot of pooled estimates of the association between dietary fat and fatty acid intake and risk of colorectal cancer. (a) Total fat intake and risk of colorectal cancer; (b) saturated fat or fatty acid and colorectal cancer; (c) monounsaturated fat or fatty acid and colorectal cancer; and (d) polyunsaturated fat or fatty acid and colorectal cancer. CI, confidence interval; n-3, omega-3 fatty acids; n-6, omega-6 fatty acids.
See this image and copyright information in PMC

References

    1. Ferlay J., Ervik M., Lam F., Colombet M., Mery L., Piñeros M., Znaor A., Soerjomataram I., Bray F. Global Cancer Observatory: Cancer Today. [(accessed on 23 October 2018)]; Available online: https://gco.iarc.fr/today.
    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2017. CA Cancer J. Clin. 2017;67:7–30. doi: 10.3322/caac.21387. - DOI - PubMed
    1. Office for National Statistics Cancer Registration Statistics, England: First Release, 2016. [(accessed on 21 May 2018)]; Available online: https://www.ons.gov.uk/releases/cancerregistrationstatisticsenglandfirst....
    1. National Cancer Institute Cancer Stat Facts: Colorectal Cancer. [(accessed on 25 May 2018)]; Available online: https://seer.cancer.gov/statfacts/html/colorect.html.
    1. Arnold M., Sierra M.S., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691. doi: 10.1136/gutjnl-2015-310912. - DOI - PubMed

LinkOut - more resources