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Meta-Analysis
. 2018 Dec 12;10(12):1963.
doi: 10.3390/nu10121963.

Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Minkyeong Kim  1 , Kyong Park  2
Affiliations
Meta-Analysis

Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Minkyeong Kim et al. Nutrients. .

Abstract

Dietary fat intake is associated with the risk of colorectal cancer (CRC); however, the results of epidemiological studies on this are controversial. Therefore, this study aimed to summarize the available scientific evidence regarding the association between dietary fat and the risk of CRC. We conducted a systematic search of PubMed, Web of Science, and the Cochrane library for articles related to dietary fat and the risk of CRC. The summary relative risks with 95% confidence intervals (CI) were calculated via a random effect model. Begg's test was used to detect publication bias. A total of 18 articles were identified. The pooled relative risk with 95% CI for the risk of CRC were 1.00 (95% CI: 0.90⁻1.12), 0.97 (95% CI: 0.86⁻1.10), 1.08 (95% CI: 0.92⁻1.26), and 0.99 (95% CI: 0.93⁻1.04) for total fat, saturated fatty acid, monounsaturated fatty acid, and polyunsaturated fatty acid, respectively. No significant associations were found in subgroup analyses. Begg's test for all exposures revealed no publication bias (total fat, p = 0.3; saturated fatty acid, p = 0.1; monounsaturated fatty acid, p = 0.08; polyunsaturated fatty acid, p = 0.2). The studies included in this review and meta-analysis revealed that dietary fats and fatty acids had no effects on the risk of CRC.

Keywords: colorectal neoplasms; dietary fats; fatty acids; meta-analysis; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram for study selection.
Figure 2
Figure 2
Forest plot of pooled estimates of the association between dietary fat and fatty acid intake and risk of colorectal cancer. (a) Total fat intake and risk of colorectal cancer; (b) saturated fat or fatty acid and colorectal cancer; (c) monounsaturated fat or fatty acid and colorectal cancer; and (d) polyunsaturated fat or fatty acid and colorectal cancer. CI, confidence interval; n-3, omega-3 fatty acids; n-6, omega-6 fatty acids.
Figure 2
Figure 2
Forest plot of pooled estimates of the association between dietary fat and fatty acid intake and risk of colorectal cancer. (a) Total fat intake and risk of colorectal cancer; (b) saturated fat or fatty acid and colorectal cancer; (c) monounsaturated fat or fatty acid and colorectal cancer; and (d) polyunsaturated fat or fatty acid and colorectal cancer. CI, confidence interval; n-3, omega-3 fatty acids; n-6, omega-6 fatty acids.
See this image and copyright information in PMC

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