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. 1978 Mar 1;147(3):940-5.
doi: 10.1084/jem.147.3.940.

Induction of partial chimerism in nonirradiated B-lymphocyte-deficient CBA/N mice

D Volf, L L Sensenbrenner, S J Sharkis, G J Elfenbein, I Scher

Induction of partial chimerism in nonirradiated B-lymphocyte-deficient CBA/N mice

D Volf et al. J Exp Med. .

Abstract

Nonirradiated B-lymphocyte-deficient CBA/N mice given T6T6 chromosome-marked normal CBA/CaHN spleen cells became lymphoid chimeras exhibiting donor-type mitoses. Normal CBA/CaHN recipients did not exhibit significant numbers of donor-type mitoses. The lymphoid cell chimerism in the CBA/N host appeared in spleen, lymph nodes, and Peyer's patches, but not in marrow or thymus. Stimulation of CBA/N-recipient spleen cells in vitro suggested that the chimerism involved donor T6T6 cells which were responsive to the B-lymphocyte mitogen, lipopolysaccharide, but not to the T-lymphocyte mitogen, phytohemagglutinin. These data indicate that stable, long-term chimerism of a specific class of lymphocytes is possible in nonirradiated, B-lymphocyte-deficient CBA/N mice.

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