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. 2019 Feb;41(2):366-373.
doi: 10.1002/hed.25505. Epub 2018 Dec 12.

Volumetric 18 F-FDG-PET parameters as predictors of locoregional failure in low-risk HPV-related oropharyngeal cancer after definitive chemoradiation therapy

Thong Chotchutipan  1   2 , Benjamin S Rosen  1 , Peter G Hawkins  1 , Jae Y Lee  1   3 , Anjali L Saripalli  1 , Dharmesh Thakkar  1 , Avraham Eisbruch  1 , Issam El Naqa  1 , Michelle L Mierzwa  1
Affiliations

Volumetric 18 F-FDG-PET parameters as predictors of locoregional failure in low-risk HPV-related oropharyngeal cancer after definitive chemoradiation therapy

Thong Chotchutipan et al. Head Neck. 2019 Feb.

Abstract

Background: We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack-year smoking history treated with chemoradiation.

Methods: A total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Cox proportional hazard modeling was used to evaluate associations of clinical and PET parameters with locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), and overall survival (OS).

Results: On univariate analysis, volumetric PET parameters were significantly associated with all endpoints, and 8th edition American Joint Committee on Cancer/Union Internationale Contre le Cancer staging was significantly associated with DMFS and OS. On multivariate analysis, total lesion TLG was significantly associated with LRFFS, while staging was most significantly prognostic for DMFS and OS.

Conclusion: Volumetric PET parameters are uniquely prognostic of LRFFS in low-risk HPV-related OPSCC and may be useful for directing de-intensification strategies.

Keywords: FDG-PET; OPSCC; TNM staging; local control; radiation oncology.

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Figures

Figure 1:
Figure 1:
Squared Pearson correlation (R2) and colorized heat map depicting inter-correlation between all tested variables
Figure 2:
Figure 2:
Kaplan-Meier plots for each endpoint by stage
Figure 3:
Figure 3:
Kaplan-Meier plots for each endpoint by total lesion TLG
Figure 4:
Figure 4:
Kaplan-Meier plots for each endpoint by total lesion MTV
See this image and copyright information in PMC

References

    1. Dahlstrom KR, Calzada G, Hanby JD, Garden AS, Glisson BS, Li G, et al. An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair. Cancer. 2013;119(1):81–9. - PMC - PubMed
    1. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35. - PMC - PubMed
    1. Ramaekers BL, Joore MA, Grutters JP, van den Ende P, Jong J, Houben R, et al. The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncol. 2011;47(8):768–74. - PubMed
    1. Stock GT, Bonadio R, de Castro GJ. De-escalation treatment of human papillomavirus-positive oropharyngeal squamous cell carcinoma: an evidence-based review for the locally advanced disease. Curr Opin Oncol. 2018. - PubMed
    1. Masterson L, Moualed D, Liu ZW, Howard JE, Dwivedi RC, Tysome JR, et al. De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials. Eur J Cancer. 2014;50(15):2636–48. - PubMed

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