Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;85(21):8037-41.
doi: 10.1073/pnas.85.21.8037.

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2

L Chen  1 , Y Mory, A Zilberstein, M Revel
Affiliations

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2

L Chen et al. Proc Natl Acad Sci U S A. 1988 Nov.

Abstract

Recombinant human interferon-beta 2 was produced in Escherichia coli by direct expression of cDNA encoding the mature protein sequence. At concentrations that stimulate DNA synthesis and growth in B-cell hybridomas and plasmacytomas, the cytokine was found to exert a strong inhibition on the growth of a number of carcinoma and leukemia/lymphoma cell lines. This antigrowth effect was observed in clonogenic assays and by measurements of cell number and thymidine incorporation in growing cultures. The effect was blocked by antibodies to a synthetic peptide from the N terminus of the molecule. Normal diploid fibroblasts were inhibited at concentrations higher than those needed for breast carcinoma cells.

PubMed Disclaimer

References

    1. EMBO J. 1983;2(9):1585-9 - PubMed
    1. Antiviral Res. 1987 Sep;8(2):55-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7152-6 - PubMed
    1. EMBO J. 1984 May;3(5):969-73 - PubMed
    1. Nature. 1985 Feb 28-Mar 6;313(6005):745-7 - PubMed

Publication types