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Comment
. 2018 Dec 13;175(7):1725-1727.
doi: 10.1016/j.cell.2018.11.037.

N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation

Dan Dominissini  1 , Gideon Rechavi  2
Affiliations
Free article
Comment

N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and Translation

Dan Dominissini et al. Cell. .
Free article

Abstract

Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.

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  • Acetylation of Cytidine in mRNA Promotes Translation Efficiency.
    Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, Hosogane M, Sinclair WR, Nanan KK, Mandler MD, Fox SD, Zengeya TT, Andresson T, Meier JL, Coller J, Oberdoerffer S. Arango D, et al. Cell. 2018 Dec 13;175(7):1872-1886.e24. doi: 10.1016/j.cell.2018.10.030. Epub 2018 Nov 15. Cell. 2018. PMID: 30449621 Free PMC article.

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