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Review
. 2018 Dec 13;19(12):4031.
doi: 10.3390/ijms19124031.

Applications of Noble Metal-Based Nanoparticles in Medicine

Bartosz Klębowski  1 , Joanna Depciuch  2 , Magdalena Parlińska-Wojtan  3 , Jarek Baran  4
Affiliations
Review

Applications of Noble Metal-Based Nanoparticles in Medicine

Bartosz Klębowski et al. Int J Mol Sci. .

Abstract

Nanoparticles have unique, size-dependent properties, which means they are widely used in various branches of industry. The ability to control the properties of nanoparticles makes these nanomaterials very interesting for medicine and pharmacology. The application of nanoparticles in medicine is associated with the design of specific nanostructures, which can be used as novel diagnostic and therapeutic modalities. There are a lot of applications of nanoparticles, e.g., as drug delivery systems, radiosensitizers in radiation or proton therapy, in bioimaging, or as bactericides/fungicides. This paper aims to introduce the characteristics of noble metal-based nanoparticles with particular emphasis on their applications in medicine and related sciences.

Keywords: antibacterial agents; bioimaging; cancer treatment; drug delivery systems (DDS); nanoparticles (NPs); radiosensitizer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various applications of Au NPs as carriers.
Figure 2
Figure 2
Scheme of the surface functionalization method of Au NPs. Au NPs—yellow circles, PEG-SH—dark blue wavy lines, ligand—green circles (modified from Reference [33]).
Figure 3
Figure 3
Interaction of X-rays with high-Z material nanoparticles (modified from Reference [49]).
Figure 4
Figure 4
Dose distribution of photons and protons.
Figure 5
Figure 5
Schematic representation of (a) photothermal, and (b) photodynamic therapy. (modified from Reference [67]).
Figure 6
Figure 6
Au NPs encapsulated in polymer nanoparticle. Au NPs—yellow circles, polymer nanoparticle—blue circle, biodegradable polyphosphazene—dark blue wavy lines. (modified from Reference [74]).
Figure 7
Figure 7
Au NPs dimers. Au NPs—yellow circles, DBDT—red circles, NH2-PEG-SH—blue wavy lines, peptide—green squares, and rhodamine—pink stars. (modified from Reference [86]).
See this image and copyright information in PMC

References

    1. McNamara K., Tofail A.M. Nanoparticles in biomedical application. Adv. Phys. X. 2007;2:54–88. doi: 10.1080/23746149.2016.1254570. - DOI
    1. Moreno-Vega A.I., Gomez-Quintero T., Nunez-Anita R.E., Acosta-Torres L.S., Castano V. Polymeric and ceramic nanoparticles in biomedical applications. J. Nanotechnol. 2012;2012:936041. doi: 10.1155/2012/936041. - DOI
    1. Chatterjee K., Sarkar S., Rao K.J., Paria S. Core/shell nanoparticles in biomedical applications. Adv. Colloid Interface Sci. 2014;209:8–39. doi: 10.1016/j.cis.2013.12.008. - DOI - PubMed
    1. Brun E., Sicard-Roselli C. Actual question raised by nanoparticle radiosensitization. Radiat. Phys. Chem. 2016;128:134–142. doi: 10.1016/j.radphyschem.2016.05.024. - DOI
    1. Hamblin M.R., Chiang L.Y., Lakshmanan S., Huang Y.Y., Garcia-Diaz M., Karimi M., de Souza Rastelli A.N., Chandran R. Nanotechnology for photodynamic therapy: A perspective from the laboratory of Dr. Michael, R. Ramblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School. Nanotechnol. Rev. 2015;4:359–372. doi: 10.1515/ntrev-2015-0027. - DOI - PMC - PubMed

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