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Multicenter Study
. 2019 Mar;15(3):465-476.
doi: 10.1016/j.jalz.2018.10.003. Epub 2018 Dec 13.

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Rosalinde E R Slot  1 , Sietske A M Sikkes  2 , Johannes Berkhof  3 , Henry Brodaty  4 , Rachel Buckley  5 , Enrica Cavedo  6 , Efthimios Dardiotis  7 , Francoise Guillo-Benarous  8 , Harald Hampel  6 , Nicole A Kochan  9 , Simone Lista  6 , Tobias Luck  10 , Paul Maruff  11 , José Luis Molinuevo  12 , Johannes Kornhuber  13 , Barry Reisberg  8 , Steffi G Riedel-Heller  14 , Shannon L Risacher  15 , Susanne Roehr  16 , Perminder S Sachdev  9 , Nikolaos Scarmeas  17 , Philip Scheltens  1 , Melanie B Shulman  8 , Andrew J Saykin  15 , Sander C J Verfaillie  1 , Pieter Jelle Visser  18 , Stephanie J B Vos  19 , Michael Wagner  20 , Steffen Wolfsgruber  20 , Frank Jessen  21 ; Alzheimer's Disease Neuroimaging Initiative; DESCRIPA working group; INSIGHT-preAD study group; SCD-I working group; Wiesje M van der Flier  22
Collaborators, Affiliations
Multicenter Study

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Rosalinde E R Slot et al. Alzheimers Dement. 2019 Mar.

Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia.

Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models.

Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia.

Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

Keywords: Alzheimer's disease; Dementia Lewy bodies; Dementia incidence; Frontotemporal dementia; Preclinical Alzheimer's disease; Subjective cognitive decline; Vascular dementia.

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Figures

Fig. 1.
Fig. 1.
Flowchart of participant selection. Overview of inclusion of participants. Abbreviations: MCI, mild cognitive impairment; SCD, subjective cognitive decline.
Fig. 2.
Fig. 2.
Type of dementia diagnosis in memory clinic and community settings. Dementia diagnoses per type of recruitment setting. Total number of dementia diagnoses: memory clinic n = 107, community n = 87. Results are represented as N (%).
Fig. 3.
Fig. 3.
Incidence rates of dementia and AD and non-AD dementia. (A) Incidence rates of dementia per decade in individuals with SCD and controls. (B) Incidence rates of AD and non-AD dementia per decade. Results are presented as incidence rates per 1000 person-years (95% Poisson confidence intervals) per decade. Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; SCD, subjective cognitive decline.
Fig. 4.
Fig. 4.
Kaplan-Meier curves of cumulative risk of dementia in controls and individuals with subjective cognitive decline in memory clinic and community cohorts. Kaplan-Meier curves of the cumulative risk of progression to dementia per decade, stratified for recruitment setting.
See this image and copyright information in PMC

References

    1. Jack CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013;12:207–16. - PMC - PubMed
    1. Sperling RA, Aisen PS, Beckett La, Bennett D, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimer’s Dement 2011; 7:280–92. - PMC - PubMed
    1. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chetelat G, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 2014;10:844–52. - PMC - PubMed
    1. Schmand B, Jonker G, Hooijer C, Lindeboom J. Subjective memory complaints may announce dementia. Neurology 1996;46:121–5. - PubMed
    1. Geerlings MI, Jonker C, Bouter LM, Ader HJ, Schmand B. Association between memory complaints and incident Alzheimer’s disease in elderly people with normal baseline cognition. Am J Psychiatry 1999;156:531–7. - PubMed

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