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Review
. 2018 Nov 10;8(20):5784-5800.
doi: 10.7150/thno.29035. eCollection 2018.

Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?

Jiaqiao Fan  1 , Dong Shang  1 , Bing Han  2 , Jianxun Song  3 , Hailong Chen  1 , Jin-Ming Yang  4
Affiliations
Review

Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?

Jiaqiao Fan et al. Theranostics. .

Abstract

The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

Keywords: adoptive cell transfer; colorectal cancer; immunotherapy.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
ACT using TILs. The specimens for preparing TILs can be obtained via surgery or puncture. These specimens can be homogenized or fragmented and then cultured. There are various protocols for the expansion of TILs in the presence of different cytokines or APC.
Figure 2
Figure 2
ACT using PBMCs. PBMCs are the most universal cell source of the ACT and are extracted from whole blood from patients or healthy donors. Various immune cells can be obtained for ACT using different protocols of cytokine management or gene edition.
Figure 3
Figure 3
Differentiated immune cells from pluripotent stem cells for the ACT. Stem cells are considered as the most promising cell source for universal production of the ACT. Stem cells can differentiate into T cells or NK cells before or after gene edition.
See this image and copyright information in PMC

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