Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jan;31(1):e13490.
doi: 10.1111/nmo.13490.

Refers to: Paul Enck. Not more, but less studies are warranted-If you take your meta-analysis seriously

Andrea S Shin  1 , Thomas F Imperiale  1
Affiliations
Comment

Refers to: Paul Enck. Not more, but less studies are warranted-If you take your meta-analysis seriously

Andrea S Shin et al. Neurogastroenterol Motil. 2019 Jan.

Abstract

This submission is in reply to a letter by Dr. Paul Enck regarding our recent conclusions regarding the clinical efficacy of patented probiotic, VSL#3, in Irritable Bowel Syndrome.

PubMed Disclaimer

Comment on

References

    1. Connell M, Shin A, James-Stevenson T, et al. Systematic review and meta-analysis: Efficacy of patented probiotic, VSL#3, in irritable bowel syndrome. Neurogastroenterol Motil 2018:e13427. - PMC - PubMed
    1. Ford AC, Quigley EM, Lacy BE, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol 2014;109:1547–61; quiz 1546, 1562. - PubMed
    1. Staudacher HM, Lomer MCE, Farquharson FM, et al. A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial. Gastroenterology 2017;153:936–947. - PubMed
    1. Kim HJ, Camilleri M, McKinzie S, et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2003;17:895–904. - PubMed
    1. Michail S, Kenche H. Gut microbiota is not modified by Randomized, Double-blind, Placebo-controlled Trial of VSL#3 in Diarrhea-predominant Irritable Bowel Syndrome. Probiotics Antimicrob Proteins 2011;3:1–7. - PMC - PubMed

LinkOut - more resources