Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Gregory Aaen¹, Michael Waltz², Wendy Vargas³, Naila Makhani⁴, Jayne Ness⁵, Yolanda Harris⁵, T Charles Casper², Leslie Benson⁶, Meghan Candee², Tanuja Chitnis⁷, Mark Gorman⁶, Jennifer Graves⁸, Benjamin Greenberg⁹, Timothy Lotze¹⁰, Soe Mar¹¹, Jan-Mendelt Tillema¹², Mary Rensel¹³, Moses Rodriguez¹², John Rose², Jennifer Rubin¹⁴, Teri Schreiner¹⁵, Amy Waldman¹⁶, Bianca Weinstock-Guttman¹⁷, Anita Belman¹⁸, Emmanuelle Waubant⁸, Lauren Krupp¹⁹

Affiliations

¹ Pediatric Multiple Sclerosis Center at Loma Linda University Children's Hospital, Loma Linda, CA, USA.
² Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
³ Pediatric Multiple Sclerosis Program, Columbia University Medical Center, New York, NY, USA.
⁴ Pediatric Multiple Sclerosis Program, Yale MS and Neuroimmunology Center, New Haven, CT, USA.
⁵ Center for Pediatric-Onset Demyelinating Disease at the Children's Hospital of Alabama, Birmingham, AL, USA.
⁶ Pediatric Multiple Sclerosis and Related Disorders Program at Boston Children's Hospital, Boston, MA, USA.
⁷ Partners Pediatric Multiple Sclerosis Center at the Massachusetts General Hospital for Children, Boston, MA, USA.
⁸ Neurology, University of California, San Francisco, CA, USA.
⁹ University of Texas Southwestern, Dallas, TX, USA.
¹⁰ The Blue Bird Circle Clinic for Multiple Sclerosis, Texas Children's Hospital, Houston, TX, USA.
¹¹ Washington University Pediatric Multiple Sclerosis and other Demyelinating Disease Center, St. Louis, MO, USA.
¹² Mayo Clinic Pediatric Multiple Sclerosis Center, Rochester, MN, USA.
¹³ Cleveland Clinic, Cleveland, OH, USA.
¹⁴ Lurie Children's Hospital, Chicago, IL, USA.
¹⁵ Rocky Mountain Multiple Sclerosis Center, University of Colorado at Denver, Aurora, CO, USA.
¹⁶ The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁷ Pediatric Multiple Sclerosis Center of the Jacobs Neurological Institute, Buffalo, NY, USA.
¹⁸ Stony Brook University, Stony Brook, New York, NY, USA.
¹⁹ Pediatric Multiple Sclerosis Center at New York University Langone Medical Center, New York, NY, USA.

PMID: 30556452
PMCID: PMC6579723
DOI: 10.1177/0883073818815041

Multicenter Study

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Gregory Aaen et al. J Child Neurol. 2019 Mar.

. 2019 Mar;34(3):148-152.

doi: 10.1177/0883073818815041. Epub 2018 Dec 17.

Authors

Affiliations

¹ Pediatric Multiple Sclerosis Center at Loma Linda University Children's Hospital, Loma Linda, CA, USA.
² Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
³ Pediatric Multiple Sclerosis Program, Columbia University Medical Center, New York, NY, USA.
⁴ Pediatric Multiple Sclerosis Program, Yale MS and Neuroimmunology Center, New Haven, CT, USA.
⁵ Center for Pediatric-Onset Demyelinating Disease at the Children's Hospital of Alabama, Birmingham, AL, USA.
⁶ Pediatric Multiple Sclerosis and Related Disorders Program at Boston Children's Hospital, Boston, MA, USA.
⁷ Partners Pediatric Multiple Sclerosis Center at the Massachusetts General Hospital for Children, Boston, MA, USA.
⁸ Neurology, University of California, San Francisco, CA, USA.
⁹ University of Texas Southwestern, Dallas, TX, USA.
¹⁰ The Blue Bird Circle Clinic for Multiple Sclerosis, Texas Children's Hospital, Houston, TX, USA.
¹¹ Washington University Pediatric Multiple Sclerosis and other Demyelinating Disease Center, St. Louis, MO, USA.
¹² Mayo Clinic Pediatric Multiple Sclerosis Center, Rochester, MN, USA.
¹³ Cleveland Clinic, Cleveland, OH, USA.
¹⁴ Lurie Children's Hospital, Chicago, IL, USA.
¹⁵ Rocky Mountain Multiple Sclerosis Center, University of Colorado at Denver, Aurora, CO, USA.
¹⁶ The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁷ Pediatric Multiple Sclerosis Center of the Jacobs Neurological Institute, Buffalo, NY, USA.
¹⁸ Stony Brook University, Stony Brook, New York, NY, USA.
¹⁹ Pediatric Multiple Sclerosis Center at New York University Langone Medical Center, New York, NY, USA.

PMID: 30556452
PMCID: PMC6579723
DOI: 10.1177/0883073818815041

Abstract

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2.2% vs 5.7%, respectively). Children with disease onset before age 11 versus onset at 11 years or after were more likely to need an individualized education plan (P = .002), reading assistance (P = .0003), and math assistance (P = .001). Children with multiple sclerosis onset prior to age 18 are not delayed in meeting the 2 major early developmental milestones but do have a significantly increased use of special services or learning assistance at school. Further research will need to address whether other measures of development (eg, rate of language acquisition or fine motor skills) differ between pediatric multiple sclerosis and controls.

Keywords: cognitive impairment; developmental milestones; multiple sclerosis; pediatric.

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Conflict of interest statement

Declaration of Conflicting Interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

1. Chitnis T, Glanz B, Jaffin S, Healy B. Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States. Multiple sclerosis. 2009;15(5):627–631. - PubMed
1. Krupp LB, Tardieu M, Amato MP, et al. International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Multiple sclerosis. 2013;19(10):1261–1267. - PubMed
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Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Affiliations

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical