[Effects of exercise on cognitive function: the possible strategy for anti-aging]

Abstract

Aging is one of the major factors which decline cognitive function associated with hippo- campus and prefrontal cortex, so it is an urgent issue to develop the practical treatment for aging brain. Since many researchers show that physical exercise can increase hippocampal neurogenesis and gray matter volume of prefrontal cortex, physical exercise is a potential candidate for preventing cognitive decline. Recently, we have reported that mild intensity exercise training enhances neurogenesis in rodents. In addition, we found long term inter- vention of mild exercise has beneficial effects on prefrontal gray matter volume and cognitive function in older adults. Based on these facts, mild exercise could be optimal strategy for anti-aging of brain.