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. 2018 Dec 15;16(12):509.
doi: 10.3390/md16120509.

Antiviral and Antioxidant Properties of Echinochrome A

Sergey A Fedoreyev  1 , Natalia V Krylova  2 , Natalia P Mishchenko  3 , Elena A Vasileva  4 , Evgeny A Pislyagin  5 , Olga V Iunikhina  6 , Vyacheslav F Lavrov  7 , Oksana A Svitich  8 , Linna K Ebralidze  9 , Galina N Leonova  10
Affiliations

Antiviral and Antioxidant Properties of Echinochrome A

Sergey A Fedoreyev et al. Mar Drugs. .

Abstract

The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

Keywords: antioxidant activity; antiviral activity; composition of antioxidants; echinochrome A.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Influence of Ech and studied formulations on the lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) formations in Vero cells. The formulations were tested at a concentration of five μg/mL. * p < 0.05; ** statistically significant differences between Asc + Toc and Ech (p ≤ 0.05).
Figure 2
Figure 2
Antiviral action of the formulations on different stages of virus replication cycles. * Statistically significant differences between Asc + Toc and other formulation (p ≤ 0.05), ** statistically significant differences between antioxidant composition and Ech (p ≤ 0.05).
See this image and copyright information in PMC

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