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. 2018 Dec 17;19(1):255.
doi: 10.1186/s12931-018-0954-1.

Pulmonary aspiration in preschool children with cystic fibrosis

D Clarke  1   2 , I Gorman  3   4 , F Ringholz  1   2 , M McDermott  2 , D W Cox  1   2 , P Greally  5 , B Linnane  1   6   7 , P Mc Nally  1   2   8
Affiliations

Pulmonary aspiration in preschool children with cystic fibrosis

D Clarke et al. Respir Res. .

Abstract

Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.

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Conflict of interest statement

Ethics approval and consent to participate

Ethics approval was obtained for this study from the Our Lady’s Children’s Hospital Ethics committee as part of the SHIELD CF research programme (The Study of Host Immunity and Early Lung Disease in CF).

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a BAL levels of Pepsin among children with CF and controls (p value 0.81), b IL-8 levels in BAL among those with CF in the high pepsin and low pepsin groups (p value 0.49), c Correlation between BAL pepsin and BAL IL-8 in children with CF, d Absolute neutrophil count in BAL among children with CF with high and low pepsin levels (p value 0.31), e Neutrophil elastase (NE) activity in BAL among children with CF with high and low pepsin levels (p value 0.98), f Correlation between BAL pepsin and BAL NE activity in children with CF
See this image and copyright information in PMC

References

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