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. 1988 Aug;25(1-2):191-4.
doi: 10.1007/BF01969111.

Failure of PAF-acether to induce in vivo neutrophil migration

F Q Cunha  1 , N E Heluy-Neto, A Klein, G E Souza, S H Ferreira
Affiliations

Failure of PAF-acether to induce in vivo neutrophil migration

F Q Cunha et al. Agents Actions. 1988 Aug.

Abstract

The ability of PAF-acether (platelet activating factor, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to induce neutrophil migration was tested in the peritoneal cavities of rats and guinea-pigs and in rat skin air pouches. PAF-acether, at doses of 2 and 5 micrograms per animal, did not promote significant neutrophil migration. The ability of PAF-acether antagonists to inhibit carrageenin induced neutrophil migration in rat abdominal cavities was also investigated. Carrageenin is a substance described to cause the release of endogenous PAF-acether. Neutrophil migration was not affected by PAF-antagonists. These observations challenge the possible role of PAF-acether as a neutrophil chemotactic factor in vivo.

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