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. 2018 Dec 18;115(51):12868-12871.
doi: 10.1073/pnas.1717157115.

Antimicrobial resistance and the role of vaccines

David E Bloom  1 , Steven Black  2 , David Salisbury  3 , Rino Rappuoli  4   5
Affiliations

Antimicrobial resistance and the role of vaccines

David E Bloom et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: R.R. is an employee of GSK group of companies.

Figures

Fig. 1.
Fig. 1.
Stanley Falkow, January 24, 1934–May 5, 2018, a pioneer in the fight to understand and address AMR. Image courtesy of Manuel R. Amieva (photographer).
Fig. 2.
Fig. 2.
A globally integrated strategy that includes antibiotics, vaccines, diagnostics, antibodies, and new tools targeting the host, the microbiome, or delivered by phages is required to fight AMR effectively. This figure was inspired by a figure in an early draft of Klemm et al. (8).
Fig. 3.
Fig. 3.
Schematic representation showing that the use of antibiotics selects for resistance (R), making the antibiotic obsolete. Therefore, a continual pipeline of new antibiotics is needed for effective treatment. In contrast, vaccines can be used for a very long time without generating significant resistance [see Kennedy and Read (11)].
Fig. 4.
Fig. 4.
Vaccines and antibiotics licensed during the last century, showing the golden era of antibiotics in 1950s, the present golden era of vaccines, and the limited pipeline of new antibiotics during the last decades.
See this image and copyright information in PMC

References

    1. Cassini A, et al. November 5, 2018. Attributable deaths and disability-adjusted live-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis. Lancet Infect Dis, 10.1016/S1473-3099(18)30605-4.
    1. U.S. Centers for Disease Control and Prevention 2018 Antibiotic/Antimicrobial Resistance. Available at https://www.cdc.gov/drugresistance/. Accessed May 7, 2018.
    1. Pumart P, et al. Health and economic impacts of antimicrobial resistance in Thailand. J Health Serv Res Policy. 2012;6:352–360.
    1. Laxminarayan R, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13:1057–1098. - PubMed
    1. The Review on Antimicrobial Resistance 2016 Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Available at https://amr-review.org/sites/default/files/160518_Final%20paper_with%20c.... Accessed May 7, 2018.

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