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. 2018 Dec 9;16(4):1559325818815019.
doi: 10.1177/1559325818815019. eCollection 2018 Oct-Dec.

Multiple Organ Lesions in a Case of Contamination With Multiple Radionuclides After 38 Years

Huahui Bian  1 , Youyou Wang  1 , Weibo Chen  1 , Yusong Zhang  1 , Zhixiang Zhuang  2 , Rui Xia  2 , Hong Dai  1 , Junchao Feng  1 , Wangyang Pu  2 , Lei Chen  2 , Wu Cai  3 , Wentao Hu  4   5 , Yulong Liu  1   4   5
Affiliations

Multiple Organ Lesions in a Case of Contamination With Multiple Radionuclides After 38 Years

Huahui Bian et al. Dose Response. .

Abstract

The patient was contaminated with multiple radionuclides 38 years ago due to an accident. To investigate the effects of radionuclide contamination on humans, he has been followed up by examinations for many years. Long-term effects gradually emerge in these years. Lung cancer was diagnosed by medical examinations. Besides, chronic gastritis with intestinal metaplasia was indicated by gastroscopic biopsies, while colorectal polyps found by colonoscopy. All 13 colorectal polyps were removed, and radical surgery for lung cancer was performed. Fortunately, pathological examinations indicated that it was early lung cancer. The ground glass nodule (GGN) in left lung identified during the follow-up will be resected when needed. It is speculated that multiple manifestations of the patient may be related to radiation, and different lesions in the organs may be related to systemic adaptive response. However, longer follow-up is needed due to a lack of effective and direct evidence. This work is expected to provide experiences for similar patients' treatment and follow-up.

Keywords: internal exposure; long-term effects; radiation carcinogenesis; radionuclide contamination.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
H&E staining of biopsy sections from gastric antrum. Microscopic observations under an Olympus BX41 with 40× (A) or 100× magnifications (B). H&E indicates haemotoxylin and eosin.
Figure 2.
Figure 2.
H&E staining of biopsy sections from colorectal polyps. Microscopic observations under an Olympus BX41 with ×40 (A) or ×100 magnifications (B). H&E indicates haemotoxylin and eosin.
Figure 3.
Figure 3.
Chest CT scanning result. CT scanning indicated a tubercle in superior lobe of right lung with local pleura invasion (A) and GGN in the upper lobe of the left lung (B). CT indicates computed tomography; GGN, ground glass nodule; H&E, haemotoxylin and eosin.
Figure 4.
Figure 4.
H&E staining of the lung adenocarcinoma sections. Microscopic observation under an Olympus BX41 with ×40 (A) or ×100 magnification (B). H&E indicates haemotoxylin and eosin.
See this image and copyright information in PMC

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