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Review
. 2018 Dec 3:9:737.
doi: 10.3389/fendo.2018.00737. eCollection 2018.

The Pathology of Hyperthyroidism

Virginia A LiVolsi  1 , Zubair W Baloch  1
Affiliations
Review

The Pathology of Hyperthyroidism

Virginia A LiVolsi et al. Front Endocrinol (Lausanne). .

Abstract

This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism.

Keywords: Graves' disease; drug reactions; ectopic hyperthyroidism; hyperfunctioning nodules; hyperthyroidism; mechanico-destructive; non-hyperthyroid; thyrotoxicosis.

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Figures

Figure 1
Figure 1
A case of Graves' disease on low power showing exuberant papillary hyperplasia.
Figure 2
Figure 2
A case of Graves' disease on medium power showing cells with round nuclei and even chromatin pattern lining the papillae.
Figure 3
Figure 3
A case of papillary hyperplastic nodule on low power showing cystic nodule with papillary architecture (arrow).
Figure 4
Figure 4
A case of papillary hyperplastic nodule on high power showing oncocytic cells lining the papillary structures (arrow).
Figure 5
Figure 5
Amiodarone associated follicular cell damage. Low and high power showing large thyroid follicles filled with colloid and numerous histiocytes (arrow heads, 3A,B).
Figure 6
Figure 6
Same as Figure 5.
See this image and copyright information in PMC

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