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. 2018 Dec;8(8):803-809.
doi: 10.1177/2192568218772568. Epub 2018 Apr 29.

The Influence of Diagnosis, Age, and Gender on Surgical Outcomes in Patients With Adult Spinal Deformity

Selim Ayhan  1   2 , Selcen Yuksel  3 , Vugar Nabiyev  1 , Prashant Adhikari  1 , Alba Villa-Casademunt  4 , Ferran Pellise  4 , Francisco Sanchez Perez-Grueso  5 , Ahmet Alanay  2 , Ibrahim Obeid  6 , Frank Kleinstueck  7 , Emre Acaroglu  1 ; European Spine Study Group
Affiliations

The Influence of Diagnosis, Age, and Gender on Surgical Outcomes in Patients With Adult Spinal Deformity

Selim Ayhan et al. Global Spine J. 2018 Dec.

Abstract

Study design: Retrospective review of prospectively collected data from a multicentric database.

Objectives: To determine the clinical impact of diagnosis, age, and gender on treatment outcomes in surgically treated adult spinal deformity (ASD) patients.

Methods: A total of 199 surgical patients with a minimum follow-up of 1 year were included and analyzed for baseline characteristics. Patients were separated into 2 groups based on improvement in health-related quality of life (HRQOL) parameters by minimum clinically important difference. Statistics were used to analyze the effect of diagnosis, age, and gender on outcome measurements followed by a multivariate binary logistic regression model for these results with statistical significance.

Results: Age was found to affect SF-36 PCS (Short From-36 Physical Component Summary) score significantly, with an odds ratio of 1.017 (unit by unit) of improving SF-36 PCS score on multivariate analysis (P < .05). The breaking point in age for this effect was 37.5 years (AUC = 58.0, P = .05). A diagnosis of idiopathic deformity would increase the probability of improvement in Oswestry Disability Index (ODI) by a factor of 0.219 and in SF-36 PCS by 0.581 times (P < .05). Gender was found not to have a significant effect on any of the HRQOL scores.

Conclusions: Age, along with a diagnosis of degenerative deformity, may have positive effects on the likelihood of improvement in SF-36 PCS (for age) and ODI (for diagnosis) in surgically treated patients with ASD and the breaking point of this effect may be earlier than generally anticipated. Gender does not seem to affect results. These may be important in patient counseling for the anticipated outcomes of surgery.

Keywords: HRQOL; MCID; adult spinal deformity; age; gender; outcome; surgery; treatment.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Selim Ayhan: None. Selcen Yuksel: None. Vugar Nabiyev: None. Prashant Adhikari: Grants/research support: Medtronic. Alba Vila-Casademunt: Grants/research support: Depuy Synthes. Ferran Pellise: Grants/research support: Depuy Synthes, K2M; Consultant: Depuy Synthes. Francisco Sanchez Perez-Grueso: Grants/research support: Depuy Synthes; Consulting: Depuy Synthes Spine. Ahmet Alanay, Grants/research support: Depuy Synthes; Consulting: Depuy Synthes, Stryker, Medtronic. Ibrahim Obeid: Grants/research support: Depuy Synthes; Consulting: Depuy Synthes, Medtronic, Alphatec. Frank Kleinstuck: Grants/research support: Depuy Synthes. Emre Acaroglu: Grants/research support: DePuy Synthes, Medtronic, Stryker Spine; Speaker’s bureau: AO Spine, Medtronic, Stryker Spine, Zimmer Biomet; Advisory board or panel: AO Spine; Stock/shareholder: IncredX (self-managed).

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