Complexity of the Basic Reproduction Number (R0)

Abstract

The basic reproduction number (R₀), also called the basic reproduction ratio or rate or the basic reproductive rate, is an epidemiologic metric used to describe the contagiousness or transmissibility of infectious agents. R₀ is affected by numerous biological, sociobehavioral, and environmental factors that govern pathogen transmission and, therefore, is usually estimated with various types of complex mathematical models, which make R₀ easily misrepresented, misinterpreted, and misapplied. R₀ is not a biological constant for a pathogen, a rate over time, or a measure of disease severity, and R₀ cannot be modified through vaccination campaigns. R₀ is rarely measured directly, and modeled R₀ values are dependent on model structures and assumptions. Some R₀ values reported in the scientific literature are likely obsolete. R₀ must be estimated, reported, and applied with great caution because this basic metric is far from simple.

Keywords: R0; basic reproduction number; basic reproduction rate; basic reproduction ratio; basic reproductive rate; disease outbreaks; infectious disease transmission; mathematical modeling; outbreaks; theoretical models.