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. 2019 Jan;25(1):190-192.
doi: 10.3201/eid2501.181136.

Severe Disease Caused by Community-Associated MRSA ST398 Type V, Australia, 2017

Geoffrey W Coombs, Stanley Pang, Denise A Daley, Yung Thin Lee, Sam Abraham, Marcel Leroi

Severe Disease Caused by Community-Associated MRSA ST398 Type V, Australia, 2017

Geoffrey W Coombs et al. Emerg Infect Dis. 2019 Jan.

Abstract

Using whole-genome sequencing, we identified a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) sequence type (ST) 398 type V (5C2&5) isolate (typically found in China) in Australia in 2017. This CA-MRSA ST398 variant was highly virulent, similar to other related CA-MRSAs of ST398. This strain should be monitored to prevent more widespread dissemination.

Keywords: Australia; Australian Staphylococcus Sepsis Outcome Programme; MRSA; MRSA and other staphylococci; PVL negative; SCCmec V; ST398; Staphylococcus aureus; V (5C2&5); antibiotic resistance; bacteria; community-associated MRSA; endocarditis; human evasion genes; livestock; livestock-associated MRSA; methicillin-resistant Staphylococcus aureus; sepsis; severe disease; spa type; t011.

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Figures

Figure
Figure
Phylogenetic tree of MRSA sequence type (ST) 398 isolate S23009-2017, recovered from a man in Australia in 2017, and related MRSA ST398 isolates from around the world (2,6,7). The tree was constructed by using single-nucleotide polymorphism differences and is rooted with MRSA ST398 isolates containing a single Panton-Valentine leukocidin locus. Isolates are grouped into clusters as described by Price et al. (6). Scale bar represents number of nucleotide substitutions per residue. CA-MRSA, community-associated MRSA; GOI, gene of interest; MRSA, methicillin-resistant Staphylococcus aureus.
See this image and copyright information in PMC

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