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. 2019 Jan;25(1):136-139.
doi: 10.3201/eid2501.180618.

Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015

Muzaffar Ali, Tahir Yaqub, Nadia Mukhtar, Muhammad Imran, Aamir Ghafoor, Muhammad Furqan Shahid, Muhammad Naeem, Munir Iqbal, Gavin J D Smith, Yvonne C F Su

Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015

Muzaffar Ali et al. Emerg Infect Dis. 2019 Jan.

Abstract

Avian influenza A(H9N2) virus isolated from a poultry worker in Pakistan in 2015 was closely related to viruses detected in poultry farms. Observed mutations in the hemagglutinin related to receptor-binding affinity and antigenicity could affect cross-reactivity with prepandemic H9N2 vaccine strains.

Keywords: Pakistan; Surveillance; avian influenza; evolution; influenza; influenza A(H9N2); poultry workers; viruses; zoonoses.

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Figures

Figure
Figure
Evolutionary relationships of the influenza A virus H9-HA gene isolated from avian and human hosts, Pakistan, 1998–2016. The phylogeny was generated using the uncorrelated lognormal relaxed molecular clock, the SRD06 codon position model, HKY85 plus gamma substitution model, and a Gaussian Markov random field (GMRF) Bayesian skyride in BEAST version 1.8.4. Two independent runs of 100 million Markov chain Monte Carlo generations were performed. Horizontal node bars represent the 95% highest posterior density intervals. Red branches indicate new sequences generated from this study, and the new human isolate is marked by a red star. Black arrows indicate the amino acid mutations (H9 numbering) for the 2015–2016 Pakistan lineage, and asterisk indicates site under positive selection.
See this image and copyright information in PMC

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