Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;25(1):140-143.
doi: 10.3201/eid2501.180270.

Puumala Hantavirus Genotypes in Humans, France, 2012-2016

Jean-Marc Reynes, Damien Carli, Damien Thomas, Guillaume Castel

Puumala Hantavirus Genotypes in Humans, France, 2012-2016

Jean-Marc Reynes et al. Emerg Infect Dis. 2019 Jan.

Abstract

The analysis of the nucleoprotein gene of 77 Puumala hantavirus strains detected in human samples in France during 2012-2016 showed that all belonged to the Central European lineage. We observed 2 main clusters, geographically structured; one included strains with the Q64 signature and the other strains with the R64 signature.

Keywords: France; Puumala virus; genotype; hantavirus; humans; orthohantavirus; viruses; zoonoses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Phylogenetic tree constructed using the maximum-likelihood approach based on the complete small-segment RNA nucleotide coding sequences of representative Puumala virus (PUUV) strains detected in human cases in France, 2012–2016 (circles), and on those published and representative of PUUV strains detected in Europe. Diamonds indicate sequences of strains detected in rodents as reported elsewhere (7,8). Bootstrap percentages >70% (from 1,000 resamplings) are indicated at each node; GenBank accession numbers are indicated for reference strains. Scale bar indicates nucleotide substitutions per site. ALAD, Alpe-Adrian lineage; CE, Central European lineage; DAN, Danish lineage; FIN, Finnish lineage; LAT, Latvian lineage; N-SCA, north-Scandinavian lineage; S-SCA; south-Scandinavian lineage; RUS, Russian lineage; MUJV, Muju virus; HOKV, Hokkaido virus.
Figure 2
Figure 2
Location of the Puumala virus small segment RNA coding domain sequence sublineages Q64 and R64 detected in human cases, by municipality of exposure, France, 2012–2016. Gray shading indicates the hantavirus-endemic area; red circles indicate Q64 sequences, by size; blue diamonds indicate R64 sequences.
See this image and copyright information in PMC

References

    1. Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O. Hantavirus infections in Europe and their impact on public health. Rev Med Virol. 2013;23:35–49. 10.1002/rmv.1722 - DOI - PubMed
    1. International Committee on Taxonomy of Viruses (ICTV). 2016.023a-cM Hantavirus approved proposal. 2017 March 19. [cited 2018 Feb 9]. https://talk.ictvonline.org/ICTV/proposals/2016.023a-cM.A.v2.Hantavirus_...
    1. Sironen T, Vaheri A, Plyusnin A. Molecular evolution of Puumala hantavirus. J Virol. 2001;75:11803–10. 10.1128/JVI.75.23.11803-11810.2001 - DOI - PMC - PubMed
    1. Razzauti M, Plyusnina A, Niemimaa J, Henttonen H, Plyusnin A. Co-circulation of two Puumala hantavirus lineages in Latvia: a Russian lineage described previously and a novel Latvian lineage. J Med Virol. 2012;84:314–8. 10.1002/jmv.22263 - DOI - PubMed
    1. Evander M, Eriksson I, Pettersson L, Juto P, Ahlm C, Olsson GE, et al. Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol. 2007;45:2491–7. 10.1128/JCM.01902-06 - DOI - PMC - PubMed

Publication types