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. 2018 Dec 17;47(6):691-693.
doi: 10.1016/j.devcel.2018.11.038.

CD44 Orchestrates Metastatic Teamwork

Christine L Chaffer  1 , Jacky G Goetz  2
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CD44 Orchestrates Metastatic Teamwork

Christine L Chaffer et al. Dev Cell. .
Free article

Abstract

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

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