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Clinical Trial
. 1988 Aug;32(8):1292-3.
doi: 10.1128/AAC.32.8.1292.

Double-blind, randomized comparison of 24 weeks of norfloxacin and 12 weeks of norfloxacin followed by 12 weeks of placebo in the therapy of complicated urinary tract infection

Affiliations
Clinical Trial

Double-blind, randomized comparison of 24 weeks of norfloxacin and 12 weeks of norfloxacin followed by 12 weeks of placebo in the therapy of complicated urinary tract infection

G J Sheehan et al. Antimicrob Agents Chemother. 1988 Aug.

Abstract

We evaluated the benefits of prolonging norfloxacin therapy from 12 to 24 weeks for complicated urinary tract infection in a double-blind, randomized, placebo-controlled study. During the second 12 weeks, norfloxacin was superior to placebo (P less than 0.05) in suppressing bacteriuria. Adverse effects were common but mostly confined to the initial 12 weeks.

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References

    1. Br Med J. 1976 Dec 11;2(6049):1411-3 - PubMed
    1. Ann Intern Med. 1975 Aug;83(2):133-47 - PubMed

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