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Review
. 2018 Dec 4:9:1436.
doi: 10.3389/fphar.2018.01436. eCollection 2018.

Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Shuqin Zhou  1   2 , Debra J Skaar  2 , Pamala A Jacobson  2 , R Stephanie Huang  2
Affiliations
Review

Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Shuqin Zhou et al. Front Pharmacol. .

Abstract

In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

Keywords: adverse drug reaction; intensive care unit; personalized medicine; pharmacogenetics; pharmacogenomics.

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Figures

Figure 1
Figure 1
Clinical actionable flow chart of drugs commonly used in ICU. (A) Codeine. (B) Voriconazole. (C) Clopidogrel. (D) Phenytoin/Carbamazepine. Develop clinical actionable flow chart based on CPIC guidelines to facility the adaptation of genomic information in clinical decision-making in ICU. Evidence-based recommendation taken from the online CPIC: Strength of Recommendations, https://cpicpgx.org/strength-of-recommendations/. * “Strong” means “the evidence is high quality and the desirable effects clearly outweigh the undesirable effects.” ** “Moderate” means “there is a close or uncertain balance as to whether the evidence is high quality and the desirable clearly outweigh the undesirable effects.”
See this image and copyright information in PMC

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