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Case Reports
. 2018 Dec 4:9:966.
doi: 10.3389/fneur.2018.00966. eCollection 2018.

First Reported Case of Neuroleptospirosis Complicated With Anton's Syndrome

Nasheeda Saeed  1 , Ching Soong Khoo  1 , Rabani Remli  1 , Zhe Kang Law  1 , Petrick Periyasamy  2 , Syazarina Sharis Osman  3 , Hui Jan Tan  1
Affiliations
Case Reports

First Reported Case of Neuroleptospirosis Complicated With Anton's Syndrome

Nasheeda Saeed et al. Front Neurol. .

Abstract

Leptospirosis is a spirochetal zoonotic disease with a wide clinical spectrum, often underdiagnosed especially when presented as an acute neurological manifestation. We report a case of a 24-year-old man with serologically positive leptospirosis, who presented with altered sensorium, seizures and subsequently developed cortical blindness. His brain MRI revealed bilateral occipital and later parietal lobe cerebritis.

Keywords: anton's syndrome; cortical blindness; electroencephalogram; neuroleptospirosis; seizures.

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Figures

Figure 1
Figure 1
Initial electroencephalogram (EEG) shows mild encephalopathy.
Figure 2
Figure 2
T2-weighted FLAIR MRI images on the axial (top left) and coronal (top right) planes exhibit abnormal hyperintense signals involving the cortices of both occipital lobes consistent with encephalitis. T1-weighted post gadolinium shows no enhancement of the affected occipital lobe (bottom left) and MR angiogram (MRA) is normal with no evidence of vasculitic changes (bottom right).
Figure 3
Figure 3
Repeated electroencephalogram (EEG) shows moderate encephalopathy with generalized periodic epileptiform discharges.
Figure 4
Figure 4
Plain (top left) and contrasted (top right) CT scans show progressive/enlarging hypodense encephalitic changes in both occipital lobes.
See this image and copyright information in PMC

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