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Case Reports
. 2018 Oct 26;6(12):2391-2395.
doi: 10.1002/ccr3.1811. eCollection 2018 Dec.

A case of prolonged generalized exanthematous pustulosis caused by hydroxychloroquine-Literature review

Fatemeh Mohaghegh  1 , Minoo Jelvan  2 , Parvin Rajabi  3
Affiliations
Case Reports

A case of prolonged generalized exanthematous pustulosis caused by hydroxychloroquine-Literature review

Fatemeh Mohaghegh et al. Clin Case Rep. .

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a self-limited drug reaction. Hydroxychloroquine (HCQ) is an uncommon cause of AGEP with a prolonged recovery course; Thus, the physicians should take the possibility of this rare but severe event in their minds and try to diagnose correctly and better management.

Keywords: acute generalized exanthematous pustulosis; hydroxychloroquine.

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Figures

Figure 1
Figure 1
Superficial intraepidermal pustules and perivascular and interstitial mixed infiltrate containing neutrophils, lymphocytes, and some eosinophils in the upper dermis. Hematoxylin and eosin, original magnification : (A) ×40, (B) ×100
Figure 2
Figure 2
Facial involvement (A) small nonfollicular pustules on the back, abdomen and forearms on erythematous skin with typical extensive postpustular desquamation (B‐D)
See this image and copyright information in PMC

References

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    1. Halevy S, Kardaun SH, Davidovici B, Wechsler J, EuroSCAR and RegiSCAR Study Group . The spectrum of histopathological features in acute generalized exanthematous pustulosis: a study of 102 cases. Br J Dermatol. 2010;163(6):1245‐1252. - PubMed
    1. Lotem M, Ingber A, Segal R, Sandbank M. Generalized pustular drug rash induced by hydroxychloroquine. Acta Derm Venereol. 1990;70:250‐251. - PubMed
    1. Martins A, Lopes LC, Paiva Lopes MJ, Rodrigues JC. Acute generalized exanthematous pustulosis induced by hydroxychloroquine. Eur Dermatol. 2006;16:317‐318. - PubMed

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