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Case Reports
. 2018 Oct 26;6(12):2411-2415.
doi: 10.1002/ccr3.1871. eCollection 2018 Dec.

A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH

Elena De Paoli  1 , Laura Bandiera  1 , Emanuele Ravano  2 , Clara Cesana  1 , Giovanni Grillo  2 , Valentina Mancini  2 , Gabriella De Canal  1 , Emanuela Bonoldi  1 , Silvia Soriani  1
Affiliations
Case Reports

A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH

Elena De Paoli et al. Clin Case Rep. .

Abstract

We describe an High-grade B-cell lymphoma case, in which a complex translocation t(3;8;14) with effects on the genes BCL6, MYC, and IGH, was detected. This case could be the first double-hit lymphoma with a single chromosome rearrangement causing the double effect with three genes involved.

Keywords: BCL6; High‐grade B‐cell lymphomas; MYC; double‐hit lymphoma; t(3;8;14); three‐way translocation.

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Figures

Figure 1
Figure 1
BM morphological evaluation: aspirate smear (1000x) (A), hematoxylin and eosin (200x) (B), Giemsa (400x) (C); Immunohistochemistry performed on BM: CD20 (100x) (D), MYC (200x) (E), COO‐panel with CD10 (100x) (F), BCL6 (100x) (G), and IRF4 (100x) (H)
Figure 2
Figure 2
QFQ‐banding on chromosomes obtained from BM cultures revealed the following complex karyotype (A). Arrows indicate rearranged chromosomes. FISH analysis performed on metaphases using MYC (B), IGH (C), and BCL6 (D) Break Apart probes revealed the presence of a three‐way chromosome rearrangement. Additional chromosome anomalies were investigated using specific probes: MEGF6 and TP73 in 1p36 (red) and ABL2 in 1q25 (green) (E); locus D13S319 in 13q14 (red) and 13q34 region (green) (F)
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References

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