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Editorial
. 2019 Jan;214(1):1-3.
doi: 10.1192/bjp.2018.246.

Treatment-resistant depression: problematic illness or a problem in our approach?

Gin S Malhi  1 , Pritha Das  2 , Zola Mannie  3 , Lauren Irwin  4
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Editorial

Treatment-resistant depression: problematic illness or a problem in our approach?

Gin S Malhi et al. Br J Psychiatry. 2019 Jan.

Abstract

Treatment-resistant depression is widely defined as non-response to two 'adequate' courses of treatment. However, the definitions of treatment and depression are inconsistent reflecting gaps in our understanding. We argue that a failure to respond is often the result of administering inappropriate treatment, which occurs principally because of paradigm failure.Declaration of interestNone.

Keywords: Depressive disorders; antidepressants; bipolar affective disorders; treatment.

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