Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatment
- PMID: 30565908
- PMCID: PMC6306284
- DOI: 10.1503/jpn.180087
Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatment
Conflict of interest statement
A. Barr has received grants from Bristol-Myers Squibb and the Canadian Institutes of Health Research. R. White has received consulting fees or sat on paid advisory boards for Janssen, Lundbeck and Otsuka and has received a grant from ThermoFisher/Affymetrix. W. Honer has received consulting fees or sat on paid advisory boards for the Canadian Agency for Drugs and Technology in Health, the Centre for Drug Research and Development, AlphaSights, In Silico (unpaid) and Otsuka/Lundbeck. R. Procyshyn has received consulting fees or sat on paid advisory boards for Janssen, Lundbeck and Otsuka; is on the speaker’s bureau for Janssen, Lundbeck and Otsuka; and has received grants from the Canadian Institutes of Health Research. D. Kim has no conflict of interest to declare.
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References
-
- Lykouras L, Alevizos B, Michalopoulou P. Obsessive-compulsive symptoms induced by atypical antipsychotics. A review of the reported cases. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:333–46. - PubMed
-
- Fineberg NA, Brown A, Reghunandanan S, et al. Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2012;15:1173–91. - PubMed
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