Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Dec 18;138(25):2940-2942.
doi: 10.1161/CIRCULATIONAHA.118.036407.

Adult Cardiac Stem Cell Concept and the Process of Science

Richard T Lee  1
Affiliations
Editorial

Adult Cardiac Stem Cell Concept and the Process of Science

Richard T Lee. Circulation. .
No abstract available

Keywords: Editorials; endothelial cells; heart failure; myocardial infarction; myocytes, cardiac; stem cells.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Significant numbers of cardiomyocytes do not arise from Sca-1+ cells.
One theory of the mammalian heart has been that cardiomyocytes arose from adult stem cells marked by the cell surface protein Sca-1. In this issue of Circulation, five reports from different laboratories using different techniques reveal that Sca-1+ cells become primarily endothelial cells and don’t appreciably contribute to the adult cardiomyocyte pool.
See this image and copyright information in PMC

Comment on

References

    1. Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO and Zhou B. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation. 2018. pii: CIRCULATIONAHA.118.034250. doi: 10.1161/CIRCULATIONAHA.118.034250. [Epub ahead of print] - DOI - PubMed
    1. Clevers H and Watt FM. Defining Adult Stem Cells by Function, not by Phenotype. Annu Rev Biochem. 2018;87:1015–1027. - PubMed
    1. Perin EC, Geng YJ and Willerson JT. Adult stem cell therapy in perspective. Circulation. 2003;107:935–938. - PubMed
    1. Parker GC. Embryonic stem cell research: the state of the union of “those who create the lines” and “those who draw the lines”. Stem Cells Dev. 2006;15:623–629. - PubMed
    1. Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S and Swamynathan SK. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics. 2016;10:10. - PMC - PubMed